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在癌症患者的手术内肠道完整性受损和术后并发症之间的关联
Sharon Hendriks1, Monique G Huisman2, Suzanne C Stokmans2
1Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. s.hendriks@umcg.nl.
Annals of surgical oncology
|January 15, 2024
概括
经外科手术时的脊柱性低 perfusion 损害了肠道完整性,通过增加肠道脂肪酸结合蛋白 (I-FABP) 表示. 较高的I-FABP水平与患者年龄,麻醉持续时间和术后并发症相关.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 关键护理医学 关键护理医学
背景情况:
- 经外科手术时的支柱体输液可以增加肠壁的透性,允许微生物转移和潜在的并发症.
- 肠脂肪酸结合蛋白 (I-FABP) 由于肠细胞损伤而释放到血中,作为肠道完整性的生物标志物.
研究的目的:
- 为了调查瘤手术期间肠道完整性损失的发生,通过I-FABP水平的变化来衡量.
- 探索肠道完整性受损,患者相关因素,手术变量和术后并发症之间的关系.
主要方法:
- 潜在的队列研究,包括接受瘤手术的患者.
- 尿液I-FABP样本采集于手术前 (T0),伤口关闭 (T1) 和术后 (1日和2日).
- 用于评估I-FABP水平与各种因素/并发症之间的关联的物流回归分析.
主要成果:
- 总共包括297名患者;中位数I-FABP水平从T0到T1显著增加 (p <0.05).
- 增加的I-FABP水平与年龄较大和更长的麻醉时间有关.
- 与没有并发症的患者相比,经历了术后并发症的患者在T1时显示出明显更高的相对I-FABP增加 (p <0.05).
结论:
- 在瘤手术期间,I-FABP水平的外科变化表明肠道完整性受到损害.
- 年龄和麻醉持续时间与I-FABP的较大增加有关.
- 术后I-FABP升高与更高的并发症发生率有关.
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