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对无机声敏器的独特洞察:设计原则和应用领域

Wen Qin^1,2, Qiaoling Yang^1,2, Chunyan Zhu^2,3

¹State Key Laboratory of Targeting Oncology, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, National Center for International Research of Biotargeting Theranostics, Guangxi Key Laboratory of Biotargeting Theranostics, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China.

Small (Weinheim an der Bergstrasse, Germany)

|January 15, 2024

概括

无机声敏剂对于声动疗法 (SDT) 在消除瘤和增强免疫力方面至关重要. 这篇评论详细介绍了它们的设计,瘤微环境调节以及癌症治疗的未来潜力.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

声动疗法 (SDT) 使用超声波和声敏剂产生反应性氧物种 (ROS) 以产生抗瘤作用.
目前的审查主要集中在有机声敏剂上,忽视了无机替代品.
需要对无机声敏剂,其设计和瘤微环境 (TME) 相互作用进行全面分析.

研究的目的:

为 SDT 提供无机声敏剂的详细审查.
根据设计的逻辑来分类无机声敏剂,并突出其化学特征.
阐明基于无机声敏化剂的纳米平台的TME调节,并探索组合疗法.

主要方法:

无机声敏剂按设计逻辑进行分类.
对作用机制和化学性质的分析.
针对TME的纳米生物技术和联合治疗策略的审查.

主要成果:

无机声敏剂为SDT提供了一个有希望的途径,产生ROS来杀死瘤细胞并激活抗瘤免疫力.
纳米平台集成无机声敏剂可以有效调节TME.
还讨论了组合疗法和除瘤学之外的应用.

结论:

无机声敏剂代表了SDT的重大进步,定制设计可以提高治疗结果.
对TME调节和组合疗法的进一步研究对非侵入性癌症治疗有很大的前景.
本综述强调了SDT中无机声敏剂的挑战和未来方向.

关键词:

综合疗法综合疗法设计原则设计原则无机声敏化剂无机声敏化剂非癌症治疗的治疗方法.调节瘤微环境的调节

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