癌症患者和癌症幸存者的COVID-19死亡率和严重程度
Jae-Min Park1,2, Hye Yeon Koo3,4, Jae-Ryun Lee3
1Department of Family Medicine, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, Korea.
Journal of Korean medical science
|January 16, 2024
概括
患有癌症的患者面临更高的COVID-19严重后果的风险,包括住院和死亡. 那些最近被诊断出癌症的人的风险最大,而癌症幸存者显示风险降低.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 癌症患者在2019年冠状病毒病 (COVID-19) 流行期间是脆弱的人群.
- 了解癌症患者的COVID-19结果对于临床管理和公共卫生策略至关重要.
研究的目的:
- 在癌症患者中调查与COVID-19相关的死亡率,严重程度和住院风险.
- 为了比较癌症患者和没有癌症患者之间的这些风险,考虑到诊断以来的时间.
主要方法:
- 利用韩国疾病控制和预防局-COVID19-国家健康保险服务 (40-79岁) 的数据.
- 包括397050名癌症患者和397050名对照人群,使用倾向分数进行匹配.
- 采用多重物流回归来分析基于癌症诊断和诊断以来的时间的COVID-19风险.
主要成果:
- 与非癌症患者相比,癌症患者在住院 (1.09),严重疾病 (1.17) 和死亡 (1.94) 的调整几率比率 (OR) 显著更高.
- 严重的COVID-19风险随着最近的癌症诊断而增加,入院的OR从1.82 (<1年) 到0.96 (幸存者) 之间.
- 诸如年龄较大,男性性别,疫苗接种不足,经济地位较低和并发症等因素也增加了COVID-19的风险.
结论:
- 癌症患者面临严重COVID-19,住院和死亡的高风险.
- 最近的癌症诊断与更高的风险有关,而癌症幸存者显示出住院和严重疾病的风险较低.
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