通过区域粘附选择精子可以改善辅助生殖治疗的结果
Rumiana Ganeva1, Dimitar Parvanov1, Nina Vidolova1
1Research and Development Department, Nadezhda Women's Health Hospital, Sofia, Bulgaria.
Andrology
|January 16, 2024
概括
使用溶解 zona pellucida 的精子选择改善了辅助生殖治疗的结果,导致更高的植入率和活产率. 这种方法还显著降低了无法解释不育的夫妇中流产率.
科学领域:
- 生殖生物学 生殖生物学
- 辅助生殖技术 (ART) 是一种助孕技术.
背景情况:
- 透明区 (zona pellucida) 作为精子透的自然屏障.
- 目前用于注射细胞内精子 (ICSI) 的精子选择方法可能不方便.
- 在ICSI中使用溶解的 zona pellucida 进行精子选择的疗效以前没有被研究过.
研究的目的:
- 为了评估精子选择的有效性,使用固定化溶解化 zona pellucida.
- 为了比较精子区域粘附选择和传统精子选择方法之间的辅助生殖治疗结果.
主要方法:
- 一项涉及368对夫妇进行冷胚胎移植的研究.
- 通过区域粘附选择精子 (研究小组,n=192) 使用酸溶解的自主 zona pellucida.
- 基于形态学标准的传统精子选择 (对照组,n=176).
主要成果:
- 精子-区域粘附组的植入率明显更高 (50.4%对37.0%).
- 在精子-区域粘附组中,临床怀孕率明显高 (43.8%与33.3%相比).
- 活产率显著改善 (38.0%对25.9%),流产率显著降低 (11.3%对22.2%).
结论:
- 使用溶解的 zona pellucida 进行精子选择,可以提高精子注射的结果.
- 这种方法对经历不明原因不孕症的夫妇尤其有益.
- 精子区域选择显著降低了流产的发生率.
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