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维生素D可以延缓椎间盘退化,并改善卵巢切除的老鼠的骨质
Hao-Wei Xu1, Xin-Yue Fang1, Hao Chen1
1Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
概括
维生素D补充剂 (VDS) 可以延迟卵巢切除的老鼠的椎间盘退化 (IDD). VDS改善了骨微观结构和抗氧化能力,为IDD提供了潜在的治疗方法.
科学领域:
- 生物医学科学 生物医学科学
- 整形外科 整形外科 整形外科
- 内分泌学 在内分泌学.
背景情况:
- 维生素D (VD) 在骨软骨代谢中起作用.
- 绝经后的女性容易患有静脉疾病缺陷和椎间盘退化 (IDD).
研究的目的:
- 调查VD补充剂是否可以延迟卵巢切除 (OVX) 的老鼠的IDD.
- 评估VD对IDD骨微观结构和抗氧化应激的影响.
主要方法:
- 经过卵巢切除的老鼠被分为虚假,OVX+VD缺乏 (VDD),OVX和OVX+VD补充 (VDS) 组.
- 在体内研究涉及成像和病理学;在体内研究使用暴露于H2O2.2.的核细胞 (NPCs).
- 评估的IDD,aggrecan/Collagen II表达,骨矿物质密度,端板多孔性,氧化还原平衡和NPC衰老/亡.
主要成果:
- 在OVX大鼠中,VDS显著缓解了IDD,而VDD则加剧了IDD.
- VDS改善了骨微观结构 (末端板的多孔性,骨矿物质密度,脊椎骨的厚度) 和增加了aggrecan/Collagen II的表达.
- VD恢复了氧化还原平衡,并保护NPC免受氧化应激,减少衰老,亡和ECM降解.
结论:
- 补充VD提供了对OVX诱导的IDD的保护作用.
- 这些好处在一定程度上通过调节氧还原平衡和维护末板微观结构来调节.
- 这表明了IDD预防和治疗的新方法.
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