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与COVID-19疫苗接种相关的疼痛与皮肤活检异常无关

Giulia Di Stefano¹, Pietro Falco¹, Eleonora Galosi¹

¹Department of Human Neuroscience, Sapienza University, Rome, Italy.

|January 16, 2024

概括

接种COVID-19疫苗可能与普遍疼痛和类似于纤维肌痛的症状有关. 虽然注意到一些感觉测试异常,但需要进一步的研究来确认接种疫苗后的小纤维神经病变.

科学领域:

神经学神经学
免疫学免疫学免疫学
疼痛医学医学疼痛医学

背景情况:

临床观察表明,COVID-19疫苗接种和小纤维神经病变之间存在潜在联系.
接种疫苗后的普遍感官症状和疼痛需要对潜在的神经病因进行调查.

研究的目的:

在COVID-19疫苗接种后经历普遍感官症状和疼痛的患者中调查潜在的小纤维损伤.
为了确定这种患者队列中纤维肌痛综合征和自主功能障碍的患病率.

主要方法:

预期招募15名患有疫苗接种后感官症状和疼痛的患者.
临床数据收集,包括复合自主症状得分-31问卷.
进行了定量感官测试 (QST),皮肤活检和心血管自主功能测试.

主要成果:

所有患者报告普遍疼痛;15人中有11人被诊断出患有纤维肌痛综合征.
所有接受测试的患者的皮肤活检和心血管自主测试都正常.
定量感官测试显示,在5名患者中,冷和热检测异常.

结论:

大多数在COVID-19疫苗接种后呈现普遍感官症状和疼痛的患者的发现与纤维肌痛综合征一致.
一些患者的异常QST发现可能表明小纤维神经病变,但需要谨慎解释.
需要进行更大规模的受控研究才能确定COVID-19疫苗接种与小纤维损伤之间的确切关联.

关键词:

接种COVID-19疫苗的时间纤维肌痛是一种纤维肌痛.定量性感官测试是一种定量性的感官测试.皮肤活检皮肤活检小纤维神经病变是一种小纤维神经病变.

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