与CKD相关的和非透析CKD的临床结果
Jennifer S Scherer1, Charlotte Tu2, Ronald L Pisoni2
1Division of Geriatrics and Palliative Care and Division of Nephrology, NYU Grossman School of Medicine, New York, NY.
Kidney medicine
|January 16, 2024
概括
慢性病 (CKD) 中的严重与更糟糕的健康结果有关. 患有CKD相关的 (CKD-aP) 的患者患有较高的死亡,住院和心血管事件风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床结果研究研究
- 流行病学 流行病学
背景情况:
- 慢性病相关的 (CKD-aP) 是慢性病 (CKD) 患者的普遍和令人痛苦的症状.
- 了解CKD-aP的临床影响对于患者的管理和改善生活质量至关重要.
研究的目的:
- 调查CKD相关的 (CKD-aP) 与非透析依赖的CKD的成年人的各种临床结果之间的关联.
- 确定CKD-aP的患病率及其与疾病严重程度,并发症和治疗模式的关系.
主要方法:
- 一项纵向队列研究涉及4,410名患有非透析依赖性CKD的成年人,来自2013年至2021年间的CKD结果和实践模式研究 (CKDopps).
- 根据皮肤的烦程度,CKD-aP是自我报告的.
- 考克斯的比例危险模型被用来分析与时间到事件结果的关联,并对混因素进行调整.
主要成果:
- 51%的患者报告说被打扰,在晚期CKD阶段,老年和更高的并发症负担中,患病率增加.
- 报告极度的患者与完全不的人相比,具有显著更高的全因死亡率 (HR 1.74),全因住院 (HR 1.56) 和心血管事件 (HR 1.84) 的风险.
- CKD-aP严重程度与CKD进展或替代疗法的开始没有显著关联.
结论:
- 严重的CKD-aP与不良的临床结果显著相关,包括非透析CKD患者的死亡率增加,住院和心血管事件.
- 这些发现强调了在CKD管理中解决的重要性,并表明治疗不足的的潜在不良后果.
- 需要进一步的研究来探索CKD-aP的机制和最佳管理策略.
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