介面和侧面轨道前皮层的连接模式发生变化,是 булимия症状严重程度的基础
Wei Li1,2, Ximei Chen1,2, Yijun Luo1,2
1Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing 400715, China.
International journal of clinical and health psychology : IJCHP
|January 16, 2024
概括
低于值的嗜食症状显示了轨道前皮层 (OFC) 连接的改变. 不同程度的食欲不良与中间和侧面OFC的不同模式相关,影响抑制控制和奖励灵敏度.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 在一般人群中,低于值的嗜食症状越来越普遍.
- 这些症状通常与轨道前皮层 (OFC) 的连接性改变有关,特别是其中间 (mOFC) 和侧面 (lOFC) 亚区域.
- 了解不同严重程度的恶食症状的独特神经支是至关重要的.
研究的目的:
- 调查不同严重程度的恶性饮食症状的成年人OFC子区域的异常功能和有效连接 (EC).
- 区分神经连接模式与严重的嗜食症 (SB) 与轻度的嗜食症 (MB) 相关.
主要方法:
- 利用静态功能连接 (FC) 和光谱动态因果建模 (spDCM).
- 分析了来自三个组的rs-fMRI数据:SB (n=21),MB (n=114) 和健康对照组 (HC,n=91).
- 应用了通用线性模型用于FC分析和spDCM用于EC估计.
主要成果:
- 无论是SB和MB组,都表现出较弱的IOFC-上顶叶连接,这表明抑制控制中的共同缺陷.
- 与MB组相比,SB组表现出较大的LOFC-occipital极连接,表明严重的嗜食症的特定神经相关性.
- 确定了mOFC与lOFC和杏仁体的定向连接,可能解释了在轻度嗜食症条件下改变的奖励灵敏度和能量平衡.
结论:
- 在LOFC和mOFC中,不同的连接模式导致了不同程度的嗜食症.
- 这些发现扩大了对 були米亚的神经生物学理解,从轻度到严重的形式.
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