患有严重喘的儿童在计算机断层扫描上有实质性的结构性气道变化
Wytse B van den Bosch1,2, Qianting Lv1,2, Eleni-Rosalina Andrinopoulou3,4
1Erasmus MC - Sophia Children's Hospital, University Medical Center Rotterdam, Department of Paediatrics, division of Respiratory Medicine and Allergology, Rotterdam, the Netherlands.
ERJ open research
|January 16, 2024
概括
在儿童中,严重的喘在CT扫描上显示出严重的气道异常,如支气管壁加厚和支气管支气管切除. 小气道疾病与儿科严重喘患者的支气管加厚有关.
科学领域:
- 肺部医学 肺部医学
- 儿科肺病学 儿科肺病学
- 放射学 放射学是一门学科.
背景情况:
- 成年人的严重喘 (SA) 与支气管壁加厚,支气管切开和低衰减区域 (LAR) 在胸部计算机断层扫描 (CT) 上有关.
- 在SA儿童中,这些结构性气道异常的患病率和程度尚不清楚.
- 这项研究旨在通过使用胸部CT检查诊断SA的儿童的呼吸道异常.
研究的目的:
- 在患有严重喘的儿童中,评估支气管壁加厚,支气管切开和低衰减区域 (LAR) 的存在和程度.
- 为了比较自动化和手动CT分析方法之间的发现.
- 探索小气道疾病 (SAD) 和支气管壁加厚之间的关系.
主要方法:
- 追溯分析了来自131名SA儿童 (平均年龄为11.0岁) 的161个吸气和呼气CT扫描.
- 使用LungQ软件进行自动分析,用于支气管树的细分和支气管壁厚度和支气管切除的测量 (定义为支气管-动脉比).
- 手动半定量评分和评估LAR和功能性小气道疾病 (SAD) 基于螺旋计.
主要成果:
- 在所有CT扫描中,自动化分析显示了95.8%的支气管切除症和支气管壁加厚.
- 手动分析显示,在28%的CT中出现支气管切除,在88.8%的CT中出现支气管壁加厚.
- 在所有CT中通过自动分析和82.9%通过手动分析观察到低衰减区域 (LAR);LAR或功能性SAD与支气管壁厚度增加相关.
结论:
- 支气管切除症和支气管壁加厚是严重喘儿童常见的结构异常,在胸部CT扫描上明显.
- 对于这些发现,自动化和手动CT分析方法之间存在重大差异.
- 小气道疾病 (SAD) 与小儿严重喘中支气管壁加厚有关.
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