高葡萄糖会通过诱导Treg细胞中的线粒体过载来损害认知功能

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Ya Hui1,2,3, Liuyu Kuang1,4, Yuanmei Zhong1,5

  • 1Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P.R. China.

iScience
|January 16, 2024
PubMed
概括

高葡萄糖会通过影响调节性T细胞 (Tregs) 在2型糖尿病中损害认知功能. 这项研究揭示了Tregs中的SP1 O-GlcNAcylation如何破坏线粒体功能,导致认知能力下降.

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人类新陈代谢的人类新陈代谢.免疫学 免疫学 免疫学

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