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Updated: Jul 5, 2025

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
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circGlis3通过与异质核核核糖核蛋白F结合并编码Glis3-348aa蛋白来促进β细胞功能障碍

Li Xiong1,2, Yingying Gong3, Huashan Liu1,2

  • 1Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

iScience
|January 16, 2024
PubMed
概括

循环RNAs (circRNAs) 调节β细胞功能,并与2型糖尿病 (T2DM) 有关. 这项研究表明,circGlis3通过影响蛋白相互作用和基因表达来损害β细胞功能,这表明它是T2DM治疗点.

关键词:
生物化学 生物化学细胞生物学 细胞生物学分子生物学分子生物学

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