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特兰胺酸局部注射对桃体切除术期间和之后的出血的影响:双盲随机安慰剂对照试验
Mojtaba Abtahi1, Amir-Abbas Kargoshai1, Hamidreza Shetabi2
1Department of Otorhinolaryngology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
World journal of plastic surgery
|January 16, 2024
概括
与安慰剂相比,局部注射的松酸 (TXA) 在桃体切除术期间或之后没有减少出血. 虽然TXA改善了外科医生的满意度,但它没有显著影响出血控制或手术持续时间.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 手术性静血 静血是指手术性静血
- 药理学 药理学是指药理学的学科.
背景情况:
- 桃体切除术是一种常见的手术,有显著出血的风险.
- 桃体切除术后出血是一种严重的并发症,需要医疗照顾.
研究的目的:
- 为了评估局部松酸 (TXA) 注射在减少在桃体切除术期间和之后出血的疗效.
- 评估TXA对外科医生满意度,血液动力学稳定性和再出血率的影响.
主要方法:
- 一个双盲,随机的安慰剂受控试验与20名桃体切除术患者进行.
- 在外科手术前10分钟,TXA局部给一侧,安慰剂给相反侧,在手术前10分钟.
- 失血,外科医生满意度,血液动力学参数 (HR,MAP) 和再出血是主要和次要结局.
主要成果:
- 在TXA和安慰剂组之间,失血量没有显著差异.
- 在TXA组中,外科医生的满意度显著更高 (p<0.05).
- 没有观察到手术持续时间,心率,平均动脉压或再出血率的显著差异.
结论:
- 局部TXA注射在桃体切除术期间或之后控制出血方面没有表现出优于安慰剂的优势.
- 虽然TXA提高了外科医生的满意度,但并没有减少手术的持续时间或预防复杂症,如再出血.
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