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基于目标的药物发现:光技术在高吞吐量和基于片段的查中的应用

Vikrant Kumar1, Puneeth Kumar Chunchagatta Lakshman1, Thazhe Kootteri Prasad1

  • 1Centre for Chemical Biology & Therapeutics, inStem & NCBS, Bellary Road, Bangalore, 560065, India.

Heliyon
|January 16, 2024
PubMed
概括

基于光的测试,如光极化 (FP) 和福斯特共振能量转移 (FRET),对于发现新疗法至关重要. 这些技术可以精确测量分子标,促进各种疾病的药物发现.

关键词:
光的两极化是因为光.基于光的测定方法基于碎片的连接体发现.福斯特共振能量转移的能量转移.G-蛋白结合受体的受体.瓜诺辛三酸酸盐酸酶是什么高吞吐量选的高吞吐量选蛋白质蛋白质相互作用基于目标的药物发现.

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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
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