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相关实验视频

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Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
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功能解码和甲分析连接性建模在甲状腺相关的眼科医生.

Qidang Duan1, Zhihong Wang2, Wunting Cheung3

  • 1School of Basic Medicine and Life Science, Hainan Medical University, Haikou, 571199, China.

Heliyon
|January 16, 2024
PubMed
概括

甲状腺相关的眼科医症 (TAO) 涉及上额回形和形/前形中大脑活动的改变,影响认知和情绪功能. 这些发现凸显了工作记忆缺陷在TAO病理生理学中的作用.

关键词:
在ALE的元分析中.上面的额头状回路 顶部的额头状回路甲状腺相关的眼睛疾病.状的 状的

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科学领域:

  • 神经科学是一个神经科学.
  • 眼科医生 眼科 眼科
  • 内分泌学 在内分泌学.

背景情况:

  • 甲状腺相关的眼病 (TAO) 是一种与甲状腺功能障碍相关的虚弱的轨道疾病.
  • 以前对TAO患者进行的神经成像研究的结果与大脑功能不一致.
  • 需要进行定量元分析,以确定TAO中大脑异常的一致模式.

研究的目的:

  • 在TAO患者中使用定量元分析识别异常大脑功能的融合模式.
  • 探索TAO中确定的大脑区域的功能连接和认知/情感关联.

主要方法:

  • 在主要数据库 (PubMed,EMBASE,Cochrane,Web of Science) 中进行了系统的文献搜索.
  • 包含了15项符合条件的研究,并使用激活概率估计 (ALE) 提取了峰值坐标进行元分析.
  • 与任务相关的元分析连接建模 (MACM) 用于分析功能连接.

主要成果:

  • 与对照人群相比,TAO患者在左上额头 (SFG) 的静止状态大脑活动增加,左/前活动减少.
  • 功能解码表明这些区域与认知和情绪障碍有关.
  • 在MACM分析中,发现了包括上顶叶,中侧前额回形和乳头等区域的显著协作激活.

结论:

  • 该研究强调了SFG和cuneus/precuneus在TAO病理生理学的参与.
  • 建议工作记忆缺陷在TAO中观察到的大脑功能改变中发挥关键作用.