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Updated: Jul 5, 2025

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
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单细胞测序与转录组测序相结合构建了多发性硬化症关键基因的预测模型,并探索了与细胞通信相关的分子机制

Fangzhou Hu1, Yunfei Zhu1, Jingluan Tian1

  • 1Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, People's Republic of China.

Journal of inflammation research
|January 16, 2024
PubMed
概括

这项研究确定了用于诊断多发性硬化症 (MS) 的四个关键基因 (CD3D,IL2RG,MS4A6A,NCF2). 使用这些基因的预测模型显示出良好的诊断效果,为MS诊断和治疗提供了新的途径.

关键词:
生物标志物生物标志物多发性硬化症多发性硬化症周围血液 周围血液预测模型 预测模型

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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