关于病毒感染的最新情况:专注于当前的治疗和预防方法
Rishika Dhapola1, Sneha Kumari1, Prajjwal Sharma1
1Department of Pharmacology, School of Health Sciences, Central University of Punjab, Bathinda, India.
Fundamental & clinical pharmacology
|January 16, 2024
概括
目前的水 (Mpox) 治疗包括抗病毒药物,如tecovirimat和cidofovir,而brincidofovir可以降低毒性. 诸如JYNNEOS等疫苗也可用于预防.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 麻疹 (Mpox) 是一种动物传播病毒,对全球健康构成重大威胁,需要对其病原和管理进行研究.
- 了解Mpox对于开发有效的治疗方法和应对策略在COVID-19等正在进行的流行病中至关重要.
研究的目的:
- 审查目前和新兴的治疗和预防策略,用于病毒 (Mpox) 感染.
- 为治疗开发提供有关Mopox病原体,症状和管理的见解.
主要方法:
- 在谷歌学者,PubMed,PubChem和世卫组织官方网站上进行文献搜索.
- 专注于确定正在进行的治疗和预防策略,以及Mpox.管道中的药物.
主要成果:
- 德科维瑞玛抑制病毒复制; 齐多福维尔向病毒DNA聚合酶,但有毒性问题,导致开发具有较低毒性的布林西多福维尔.
- 利巴维林通过抑制IMPDH和酶活性来破坏病毒转化. 其他潜在的药物,如提亚佐富林,腺素N1氧化物和HPMPA在体外显示有效性.
- 在的研究表明,尼洛丁尼,西梅普雷维尔和二欧哥他胺与必不可少的MPXV蛋白质结合. 诸如JYNNEOS,ACAM2000和VIGIV等疫苗用于预防.
结论:
- 本综述总结了Mpox.的病变发生,临床表现,以及Mpox.的可用/管道治疗方法和疫苗.
- 这些发现突出了Mpox治疗和预防的关键药物和疫苗,有助于疾病管理.
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