基因组范围的相互作用分析与DASH饮食得分确定了系统性血压的新型位置点
Mélanie Guirette1, Jessie Lan1, Nicola M McKeown2
1Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (M.G., J.L., J.M.).
Hypertension (Dallas, Tex. : 1979)
|January 16, 2024
概括
这项研究发现基因与饮食的相互作用会影响血压,特别是在DASH饮食中. 需要对不同种群进行进一步的研究,以确认这些与高血压的遗传联系.
科学领域:
- 遗传学 遗传学 是一个
- 营养科学 营养科学
- 心血管健康 心血管健康
背景情况:
- 停止高血压的饮食方法 (DASH) 饮食已知可以降低血压 (BP).
- 遗传变异可能会影响个体对DASH饮食等饮食干预措施的反应.
研究的目的:
- 研究基因变异 (基因型) 与DASH饮食得分之间的相互作用,与缩血压 (SBP) 相比.
- 确定特定的基因位置,其中饮食-DASH相互作用影响SBP.
主要方法:
- 全基因组关联分析对来自心脏和衰老研究在基因组流行病学 (CHARGE) 联盟和英国生物银行的127,000多个个体的多达9,420,585个单核酸多态 (SNPs) 进行.
- 对欧洲人口和不同人口群体进行了单独的元分析,以确定基因-DASH饮食得分相互作用.
主要成果:
- 七个基因位点与SBP (P<5e-8) 显示出显著的基因饮食相互作用,其中三个在欧洲特定分析中确定,四个在跨种群分析中确定.
- 在15q25.1的rs117878928与欧洲人口的DASH饮食得分 (P=4e-8) 观察到一致的相互作用.
- 围绕rs117878928的区域显示了cis表达和cis-DNA甲基化定量特征位点的丰富,这表明了调节作用,ST20被确定为潜在的相互作用基因.
结论:
- 显著的基因-DASH饮食得分相互作用影响缩血压被确定在多个遗传位置.
- 这些发现凸显了遗传因素在调节DASH饮食降血压效应中的作用.
- 为了验证这些基因饮食相互作用发现,需要更大,更多样化的研究群体.
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