四级氨结合的高分支聚尿素纳米组合与抗生素协同作用,增强了抗菌疗效
Yanwen Feng1, Jiang Bian1, Guoyi Yu1
1School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong 518107, P. R. China. yuejun3@mail.sysu.edu.cn.
Biomaterials science
|January 16, 2024
概括
研究人员开发了一种新型的纳米载体,高分支多尿素与四级 (HPU-QA),用于有效地将抗生素输送到细菌生物膜. 这种纳米载体在治疗生物膜感染和促进伤口愈合方面表现有前途.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 传染性疾病 传染性疾病
背景情况:
- 向生物膜输送抗生素仍然是治疗持续性细菌感染的一个重大挑战.
- 生物膜矩阵阻碍药物透,降低治疗疗效.
- 需要新的策略来增强抗生素的运输和对生物膜的活性.
研究的目的:
- 开发和评估一种新的纳米载体系统,以改善对细菌生物膜的抗生素输送.
- 评估开发的纳米载体在治疗生物膜相关感染和促进伤口愈合方面的有效性.
主要方法:
- 作为纳米载体,合成四级结合的高分支多尿素 (HPU-QA).
- 在HPUs-QA纳米载体上加载一种模型抗生素 - - 利芬素.
- 在体外评估抗生素负载能力和生物膜透率.
- 在体内评估细菌感染模型的伤口愈合.
主要成果:
- 该HPUs-QA纳米载体表现出高负载能力的利芬素.
- 装有里芬素的HPUs-QA纳米组件 (HPUs-Rif/QA) 有效地将抗生素输入生物膜.
- 在HPUs-Rif/QA中,针对浮游生物细菌和生物膜的协同抗微生物作用得到了证明.
- 与单个成分相比,HPUs-Rif/QA通过抑制细菌殖民,显著增强了伤口愈合.
结论:
- 开发的HPUs-QA纳米组件是协同抗生素输送的有希望的平台.
- 这种纳米载体系统为应对具有挑战性的生物膜相关感染提供了潜在的策略.
- 这些发现支持在组合疗法中使用HPUs-QA,以改善治疗结果.
更多相关视频
11:19Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties
Published on: May 10, 2018
10.3K
08:08Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
Published on: August 4, 2018
22.1K
相关概念视频
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
01:26Urine Studies II: Urine Culture and Sensitivity Test
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
01:27Production of Antibiotics
Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...
01:25Mechanism of Antibiotic Resistance in MRSA
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...