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在多发性硬化症中成像慢性活跃病变:一个共识声明

Francesca Bagnato^1,2, Pascal Sati³, Christopher C Hemond⁴

¹Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA.

Brain : a journal of neurology

|January 16, 2024

概括

新的成像生物标志物可以检测多发性硬化症 (MS) 大脑中的慢性活性病变 (CAL). 一份共识声明为它们的放射性定义和测量提供了指导,以帮助临床翻译.

科学领域:

神经成像是一种神经成像.
神经学神经学
炎症研究的研究.

背景情况:

慢性活跃病变 (CAL) 是多发性硬化症 (MS) 慢性炎症的关键指标,影响疾病进展.
最近的MRI和PET成像技术的进步允许在体内检测和量化MS患者的CAL.

研究的目的:

提出北美多发性硬化成像合作社关于CAL的放射性定义和测量的一致声明.
总结本共识声明的开发过程,并突出现有的知识差距.

主要方法:

对用于CAL检测的创新型MRI和PET衍生生物标志物的审查,包括偏磁边缘病变和18kDa转位蛋白阳性病变.
制定一个共识声明,为CAL识别,量化和监测提供放射学指导.

主要成果:

确定CAL有前途的候选生物标志物,如磁性边缘病变和MRI上的缓慢扩张病变,以及PET上的18kDa转位蛋白阳性病变.
承认当前的生物标志物与基因病学CAL相比具有重叠但不相等的灵敏度和特异性.
强调目前对CAL的成像测量缺乏标准化.

结论:

达成共识的声明为标准化各成员国的CAL评估提供了关键的指导.
需要进一步的研究来解决剩余的知识差距,并完善成像生物标志物,以便更准确地检测和监测CAL.

关键词:

通过MRI定义的缓慢发展的病变.长期活跃的病变慢性活跃的病变铁是铁,铁是铁,铁是铁.微质细胞中的微质细胞多发性硬化症多发性硬化症偏磁边缘损伤的病变

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