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Updated: Jul 5, 2025

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导致早期痴呆症并增加阿尔茨海默病风险的TREM2变体会影响基因拼接

Kostantin Kiianitsa1, Maria E Lukes2, Brian J Hayes3

  • 1Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.

Brain : a journal of neurology
|January 16, 2024
PubMed
概括

在骨髓细胞2 (TREM2) 变体上表达的触发受体会通过改变的拼接引起神经退行性疾病. 这项研究揭示了TREM2变体中的拼接缺陷,影响了阿尔茨海默病和前性痴呆风险.

关键词:
替代性拼接是一种替代性的拼接.脑子 脑子 脑子 大脑突出跳过的突出跳过基因剂量 基因剂量微质细胞中的微质细胞神经退行症的神经退行症

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