JAK2V617F在患有骨髓增殖性瘤的患者中驱动肠道微生物群的差异
Christina Schjellerup Eickhardt-Dalbøge1,2,3, Henrik V Nielsen3, Kurt Fuursted3
1The Regional Department of Clinical Microbiology, University Hospital of Region Zealand, Slagelse, Denmark.
European journal of haematology
|January 16, 2024
概括
骨髓增殖性瘤 (MPN) 患者的肠道微生物群与健康对照群不同,JAK2V617F突变显著影响肠道细菌. 阳性CALRMPN患者的肠道微生物群与健康个体更相似.
科学领域:
- 血液学 血液学 血液学
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 骨髓增殖性瘤 (MPNs),包括基本血小板血 (ET),真多细胞血 (PV) 和原发性骨髓纤维化 (MF),与炎症有关.
- 肠道微生物群在免疫功能,抗感染能力和维持正常的血细胞生产 (血液形成) 中起着至关重要的作用.
研究的目的:
- 为了研究MPN患者和健康对照者之间的肠道微生物组合的差异.
- 探索特定的MPN突变,如JAK2V617F和CALR,如何影响肠道微生物群.
主要方法:
- 下一代测序用于分析227名MPN患者和42名健康对照者的肠道微生物群.
- 总体而言,MPN患者,特定的MPN亚诊断,以及具有不同MPN突变的个体与健康对照者进行了比较.
主要成果:
- 与健康对照组相比,MPN患者表现出更大的肠道微生物丰富性.
- 在MPN患者中观察到更少的Firmicutes,包括Faecalibacterium.
- CALR阳性MPN患者的肠道微生物群与健康对照群的肠道微生物群相比,与JAK2V617F突变患者的肠道微生物群相似.
结论:
- 与健康个体相比,MPN患者的肠道微生物群组成发生了变化.
- JAK2V617F突变是MPN肠道微生物群变化的重要驱动因素.
- 有CALR突变的MPN患者的肠道微生物群概况与健康对照群更相似.
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