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功能化塑料表面对抗人类冠状病毒的抗病毒作用

Sailee Shroff¹, Marjo Haapakoski¹, Kosti Tapio^2,3

¹Department of Biological and Environmental Sciences, Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland.

Microbiology spectrum

|January 16, 2024

概括

一种新型的塑料表面与高油合剂功能化,有效地在几分钟内使人体冠状病毒失活. 这种抗病毒塑料提供了一个主动的策略,以减少疫情期间在表面的病毒传播.

科学领域:

材料科学材料科学材料科学
病毒学病毒学
表面化学表面化学

背景情况:

病毒可以在表面存活,从而促进间接传播.
开发功能化的表面对于减少日常生活中的病毒负载至关重要.
在疫情爆发期间,抗病毒表面可以补充现有的卫生做法.

研究的目的:

为了测试用高油树脂功能化的塑料表面的抗病毒性质.
评估对季节性人类冠状病毒OC43和严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 的疗效.
确定抗病毒作用的机制及其对湿度等环境因素的依赖.

主要方法:

在非功能化和合金功能化塑料表面测试病毒的持久性.
评估各种接触时间和湿度水平 (20%,40%,>90%) 的抗病毒功效.
利用离子显微镜,传输电子显微镜和原子力显微镜研究病毒结构变化.
研究液在病毒无活化中的作用.

主要成果:

非功能化的塑料表面显示病毒持续长达48小时.
素功能化塑料在15分钟内表现出快速的抗病毒作用,在30分钟内,无论湿度如何,有效率>90%.
病毒在接触后的结构变化很小,但无法感染宿主细胞,这表明在内体细胞阶段停止融合.
化合金证实了其禁用病毒的能力,这表明主动浸出是主要机制.

结论:

高油合剂功能化的塑料表面对包括冠状病毒在内的包裹病毒具有强大和快速的抗病毒活性.
抗病毒效应归因于液中的素成分,这些成分在内体细胞阶段抑制病毒进入宿主细胞.
这种功能化塑料是开发减少日常环境中病毒传播的表面的有希望的候选人.

关键词:

抗病毒的表面抗病毒.人类新冠肺炎病毒塑料的塑料塑料的塑料塑料的塑料的塑料高油罗辛,高油罗辛是一种高油.病毒持久性病毒持久性

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