验证Mitra®和VAMS®作为采用ICP-MS/MS进行微量元素分析的采血技术
Anthony Breton1,2, Ciprian Mihai Cirtiu1,2, Cyril Muehlethaler2
1Institut National de Santé Publique du Québec (INSPQ), Centre de Toxicologie du Québec (CTQ), 945 Wolfe, Quebec, G1V 5B3, Canada.
Bioanalysis
|January 16, 2024
概括
体积吸收微采样 (VAMS) 为采集血液提供了一个有前途的替代方案,而不是传统的静脉穿刺. 这种微采样方法为微量元素分析提供了准确和可重复的结果.
科学领域:
- 分析化学 分析化学
- 临床诊断 临床诊断 临床诊断
- 生物医学工程 生物医学工程
背景情况:
- 传统的静脉穿刺采集血液具有局限性,不适合所有人.
- 卷度吸收微采样 (VAMS) 正成为一种具有潜在优势的不那么侵入性的替代方案.
- 准确量化血液中的有毒和必需元素对于临床剂量和监测至关重要.
研究的目的:
- 开发和验证一种使用VAMS.用全血量化元素的方法.
- 评估VAMS的性能与既定参考方法相比.
- 评估VAMS作为微量元素分析中静脉穿刺的潜在替代方案.
主要方法:
- 开发和验证使用感应合等离子体双重质谱法 (ICP-MS/MS) 的量化方法.
- 通过VAMS收集的全血样本的分析.
- 将VAMS结果与使用全血样本的参考方法进行比较.
主要成果:
- 开发的VAMS方法证明了对大多数目标元素的准确和可重复量化.
- 验证和性能评估证实了微采样技术的可靠性.
- 结果显示与参考方法有很强的一致性,表明高精度和准确性.
结论:
- 在微量元素分析中,VAMS显示出作为静脉穿刺可行的替代品在血液采样中的显著潜力.
- 微采样技术为某些元素分析提供了不那么侵入性和更容易获得的方法.
- 需要进行进一步的研究,以充分确定VAMS在基本诊断中常规临床使用.
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