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在症状出现后,SARS-CoV-2病毒复制在人类肺部持续数周

Michele Tomasicchio^1,2, Shameem Jaumdally^1,2, Lindsay Wilson^1,2

¹Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.

American journal of respiratory and critical care medicine

|January 16, 2024

概括

复制SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 在症状出现后,可以在肺部持续数周,导致炎症和增加死亡率,特别是在三角洲变种. 这种特定于肺部的复制影响了COVID-19患者的管理.

科学领域:

肺部医学肺部医学
病毒学病毒学
病理学病理学病理学

背景情况:

复制的SARS-CoV-2通常在8天内从上呼吸道清除.
关于病毒在下呼吸道 (肺) 中复制的持续时间和频率的数据有限.

研究的目的:

调查已故COVID-19患者肺部中可培养的SARS-CoV-2的存在和持续时间.
描述肺部特异性病毒复制表型及其与临床结果的关联.

主要方法:

在Beta和Delta波期间,对42名机械通风的死者进行了肺组织针活检.
分析包括病毒培养,组织病理学,电子显微镜,转录组学和免疫组织化学.
门诊患者作为对照组.

主要成果:

可培养的SARS-CoV-2在38%的死者的肺部中被发现,在症状出现后4周内.
肺病毒阳性与加速死亡和二次细菌感染有关.
尽管肺部培养物呈阳性,但鼻口腔扫描在23.1%的病例中呈阴性,这表明肺部特异性复制.

结论:

持续的SARS-CoV-2肺复制导致疾病第二周以后的炎症反应加剧.
这种肺部特异性的病毒持久性与死亡率和发病率的增加有关,特别是在特定变异的情况下.
研究结果表明,这对严重的COVID-19的干预策略和临床管理有意义.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.机械通风患者的机械通风患者.在上呼吸道上部呼吸道.病毒复制是病毒的复制.

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