1975年至2019年美国乳腺癌死亡率分析
Jennifer L Caswell-Jin1, Liyang P Sun2, Diego Munoz2
1Department of Medicine, Stanford University School of Medicine, Stanford, California.
JAMA
|January 16, 2024
概括
由于查和治疗的进步, 美国的乳腺癌死亡率大幅下降. 早期和转移性乳腺癌的治疗,以及乳房扫描,从1975年到2019年,总体降低了58%的死亡率.
科学领域:
- 癌症学
- 公共卫生
- 生物统计学
背景情况:
- 美国乳腺癌死亡率在1975年至2019年期间下降.
- 转移性乳腺癌治疗对这种下降的具体影响尚不清楚.
研究的目的:
- 模拟乳腺癌查,早期 (I- III) 治疗和转移性治疗与乳腺癌死亡率降低之间的关联.
- 量化这些干预措施对降低死亡率的相对贡献.
主要方法:
- 使用了4个癌症干预和监测建模网络 (CISNET) 模型.
- 从1975年到2019年使用综合观察和临床试验数据模拟的美国乳腺癌死亡率.
- 评估了经年龄调整的死亡率和转移后复发的中位生存率.
主要成果:
- 与1975年相比,2019年乳腺癌死亡率降低了58%,这是由于查和治疗.
- 治疗I-III阶段的乳腺癌占这一减少的47%.
- 转移性乳腺癌的治疗贡献了29%,而乳房检查贡献了25%.
结论:
- 乳腺癌查和治疗在1975年至2019年间显著降低了美国的死亡率.
- 治疗早期和转移性疾病以及查对于改善生存结果至关重要.
- 转移性复发后的中位生存时间大大改善,特别是在ER阳性/ ERBB2阳性乳腺癌中.
相关概念视频
Cancer Survival Analysis
353
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
353
Comparing the Survival Analysis of Two or More Groups
195
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
195
Kaplan-Meier Approach
146
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
146
Introduction To Survival Analysis
239
Survival analysis is a statistical method used to study time-to-event data, where the "event" might represent outcomes like death, disease relapse, system failure, or recovery. A unique feature of survival data is censoring, which occurs when the event of interest has not been observed for some individuals during the study period. This requires specialized techniques to handle incomplete data effectively.
The primary goal of survival analysis is to estimate survival time—the time...
The primary goal of survival analysis is to estimate survival time—the time...
239
Actuarial Approach
79
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
79
Statistical Methods for Analyzing Epidemiological Data
367
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
367


