EORTC QLQ-C30的基线功能尺度预测胃肠道癌症患者的整体存活率:一个元分析
Ye Zang1, Yue Qiu2, Yimeng Sun3,4
1Department of Oncology, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang, 212399, China.
概括
生活质量 (QoL) 显著影响胃肠道癌症患者的生存率. 在 EORTC QLQ-C30 上,全球和身体功能评分较差,预测整体存活率 (OS) 降低.
科学领域:
- 在瘤学瘤学.
- 健康 结果 研究 研究 结果
- 心理社会瘤学
背景情况:
- 生活质量 (QoL) 在胃肠癌 (GI) 存活率的预后价值仍在争论中.
- 欧洲癌症研究和治疗组织生命质量问卷核心30 (EORTC QLQ-C30) 是一个广泛使用的衡量标准.
研究的目的:
- 在肠道癌患者中对EORTC QLQ-C30功能表和整体存活率 (OS) 之间的关联进行元分析.
- 为了澄清基线QoL在肠道癌症的预后作用.
主要方法:
- 在PubMed,Web of Science和Embase数据库进行系统的文献搜索,截至2023年2月7日.
- 包括评估基线QOL (EORTC QLQ-C30功能尺度) 和胃肠道癌的OS的研究.
- 对调整后的危险比率 (HR) 和95%置信区间 (CI) 的元分析,以确定预后能力.
主要成果:
- 分析了22篇涉及11,609名患者的文章.
- 较差的整体体质量 (HR 1.81),身体功能 (HR 1.51),社会功能 (HR 1.67) 和角色功能 (HR 1.42) 与OS降低有关.
- 全球QOL,身体功能和角色功能每增加10个点,预计会改善OS (HR分别为0.87,0.87,0.93).
结论:
- 基线与健康相关的QoL,特别是全球的QoL和身体功能,显著预测胃肠癌的整体存活率.
- 这些发现强调了QoL评估在癌症预后中的重要性.
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