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外体非编码RNA作为膀癌的非侵入性生物标志物:一个诊断元分析

Liming Zhao¹, Jun Li¹, Zhongguang Xue¹

¹Department of Nuclear Medicine, Linyi People's Hospital, Shandong University, 27 Jiefang Road, Linyi, 276003, Shandong, People's Republic of China.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

|January 16, 2024

概括

血液和尿液中的外体非编码RNA (ncRNA) 显示为膀癌检测的非侵入性生物标志物具有前途. 这一元分析证实了它们的诊断效果,microRNAs表现出卓越的性能.

科学领域:

生物标志物生物标志物
在瘤学瘤学.
分子诊断学分子诊断

背景情况:

现有报告中的差异需要对外体非编码RNAs (ncRNAs) 进行全面评估,以检测膀癌.
研究血液和尿液中的外体ncRNA的诊断疗效对于推进非侵入性诊断策略至关重要.

研究的目的:

进行元分析,评估血液和尿液中的外体非编码RNAs (ncRNAs) 的诊断疗效,以检测膀癌.
为了比较不同类型的外体ncRNA的诊断值,包括微RNA (miRNA) 和长非编码RNA (lncRNA).

主要方法:

从PubMed,Cochrane图书馆和Embase系统地检索文献.
使用STATA 12.0,Meta-DiSc 1.4和RevMan 5.3.3进行的元分析
通过总结接收器操作特征 (SROC) 曲线下的区域评估聚合诊断疗效;通过子组分析和元回归探索异质性.

主要成果:

包括46项研究,包括2622名对照组和3015名膀癌患者.
血液和尿液中的外体ncRNA显示出令人满意的诊断疗效 (聚合灵敏度0.75,特异性0.79,AUC0.84).
外体miRNAs (AUC 0.91) 在诊断价值方面表现优于外体 lncRNAs;已确定异质性来源.

结论:

血液和尿液中的外体ncRNA显示出作为膀癌诊断的非侵入性生物标志物的潜力.
需要进一步的大规模前性研究来证实这些生物标志物的临床实用性.

关键词:

膀癌是一种癌症.异构体是什么? 异构体是什么? 外构体是什么?进行元分析分析.它们是ncRNAs.非侵入性诊断是一种非侵入性诊断.

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