英国哥伦比亚省更安全的阿片类药物供应政策和阿片类药物结果
Hai V Nguyen1, Shweta Mital2, Shawn Bugden1
1School of Pharmacy, Memorial University, St John's, Newfoundland and Labrador, Canada.
JAMA internal medicine
|January 16, 2024
概括
英国哥伦比亚省的安全阿片类药物供应政策增加了阿片类药物处方和索赔者,但也导致了更多与阿片类药物相关的住院治疗. 该政策没有显著影响阿片类药物毒性死亡.
科学领域:
- 公共卫生 公共卫生
- 药物使用障碍 药物使用障碍
- 卫生政策 卫生政策
背景情况:
- 2020年3月,不列颠哥伦比亚省为患有阿片类药物使用障碍的人士推出了全省安全供应政策.
- 这一政策旨在为高风险人群提供药品级阿片类药物.
- 政策实施后与阿片类药物相关的结果之前没有被分析过.
研究的目的:
- 调查不列颠哥伦比亚省更安全的阿片类药物供应政策与阿片类药物处方模式之间的联系.
- 检查政策对阿片类药物相关健康结果的影响,包括住院治疗和死亡.
主要方法:
- 一项队列研究利用了2016年1月至2022年3月的季度省级数据.
- 英国哥伦比亚省 (政策实施) 与曼尼托巴省和萨斯喀彻温省 (没有政策) 相比.
- 差异分析评估了阿片类药物处方,索赔者,处方者,中毒住院和明显阿片类毒性死亡的变化,在政策实施前后.
主要成果:
- "更安全的阿片类药物供应政策"与阿片类药物处方和索赔者的显著增加有关.
- 在处方者数量上没有观察到显著变化.
- 在政策实施后,与阿片类药物相关的中毒住院病例显著增加.
结论:
- 在不列颠哥伦比亚省,更安全的阿片类药物供应政策与更安全的阿片类药物处方增加有关.
- 这一政策还与阿片类药物中毒相关住院病例的显著增加有关.
- 调查结果为不列颠哥伦比亚省和其他考虑采取类似举措的司法管辖区的政策讨论提供了见解.
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