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Updated: Jul 5, 2025

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Published on: January 16, 2016

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在KPC-2β-乳酸酶中N170在基质辅助脱中的结构性作用

Diksha Parwana1, Jing Gu1, Shuang Chen1

  • 1UCL School of Pharmacy, London, UK.

Angewandte Chemie (International ed. in English)
|January 16, 2024
PubMed
概括

在Klebsiella pneumoniae carbapenemase 2 (KPC-2) 中氨基酸的变化导致对ceftazidime-avibactam的耐药性. 模拟揭示了特定突变,特别是D179如何破坏酶.

关键词:
加强采样 加强采样形态动力学是什么意思基质辅助催化剂的使用这是β-lactam抗生素的抗生素.这就是β-乳酸酶.

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