叙述偏见 ("旋转") 在随机试验和对止痛大麻素的系统评价中很常见
Andrew Moore1, Paige Karadag2,3, Emma Fisher4
1Court Road, Newton Ferrers, Plymouth, United Kingdom.
Pain
|January 16, 2024
概括
科学摘要中的叙述偏见或"旋转"可能会误导读者. 大约五分之一的止痛药研究表明这种偏见,影响了对疗效和安全的看法.
科学领域:
- 医学研究方法论医学研究方法论.
- 临床试验报告报告
- 基于证据的医学是基于证据的医学.
背景情况:
- 叙事偏见,通常称为"旋转",涉及向叙事提供信息,以适应叙事,可能扭曲科学发现.
- 科学摘要至关重要,因为它们经常是研究人员和临床医生阅读文章的唯一部分.
- 评估叙事偏见的现有工具不足以评估与疼痛相关的研究中的疗效和安全性声明.
研究的目的:
- 开发和验证一种用于检测科学文章标题和摘要中叙事偏见的新型工具.
- 评估关于大麻素和基于大麻的止痛药物的随机试验和系统审查中叙述偏见的流行程度和特征.
主要方法:
- 创建了一个6点的工具来识别标题和摘要中的叙事偏见.
- 该工具应用于对大麻素/大麻制止疼痛药物的随机对照试验 (RCT) 和系统审查 (SRs),文献搜索更新至2021年4月.
- 进行了相关性和集群分析,以检查叙事偏见和研究特征之间的关联.
主要成果:
- 在24%的RCT和17%的SR中检测到中度到严重的叙述偏差.
- 叙述偏见同样影响了有效性和安全性报告.
- 在叙事偏见和研究特征之间没有发现显著的关联.
- 所有检测到的偏见都倾向于实验性大麻素或基于大麻的药物.
结论:
- 关于止痛药的大量研究在标题和摘要中表现出叙事偏见.
- 这种偏见可能导致误解治疗有效性或安全性,当仅依赖于摘要时.
- 开发的工具有效地识别了叙事偏见,强调了对研究摘要的批判性评估的需要.
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