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Updated: Jul 5, 2025

Single Molecule Fluorescence Energy Transfer Study of Ribosome Protein Synthesis
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在无细胞系统中对核糖体的直接可视化揭示了aminoglycoside的功能进化

Junta Tomono1, Kosuke Asano1, Takuma Chiashi1

  • 1Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.

Journal of biochemistry
|January 16, 2024
PubMed
概括

一种新的冷电子显微镜方法,在无细胞翻译系统 (DARC) 中直接可视化抗生素对核糖体的结合,可视化了抗生素对核糖体的作用. 这种方法揭示了抗生素进化如何增强药物开发的结合亲和力.

关键词:
抗生素 抗生素是一种抗生素.核糖体结构<RNA 核糖体翻译 < RNA 的 RNA.冷电子显微镜的使用方法结构生物学结构生物学

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