来自Sporidiobolus pararoseus的细胞外多糖类通过改善肠道屏障功能和肠道微生物群来缓解类风湿
Tingting Liao1, Fanglin Shen2, Hongkang Zhu1
1State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province 214122, PR China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu Province 214122, PR China; School of Food Science and Technology, Jiangnan University, No.1800 Lihu Avenue, Wuxi, Jiangsu Province 214122, PR China.
聚糖 (SPP) 通过减少关节炎症和重塑肠道微生物群,有效治疗类风湿性关节炎 (RA). SPP增加有益的细菌和短链脂肪酸,恢复免疫平衡并缓解RA症状.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 类风湿性关节炎 (RA) 是一种普遍存在的自身免疫性疾病,常规治疗对其有不良影响.
- 需要新的治疗策略来有效管理RA.
- 葡萄糖多糖 (SPP) 具有免疫刺激和抗氧化特性.
研究的目的:
- 在风湿性关节炎 (RA) 的小鼠模型上研究SPP的治疗效果.
- 探索SPP干预RA的潜在机制,重点关注肠道微生物群调节.
主要方法:
- 建立了一种II型原诱导性关节炎 (CIA) 鼠标模型,以模拟RA.
- 进行SPP干预,以评估其对关节炎症状和炎症标志物的影响.
- 使用16SrRNA测序分析了肠道微生物群组成的变化.
- 测量了短链脂肪酸 (SCFA) 的水平,以评估它们的生产.
主要成果:
- 在CIA小鼠中,SPP干预显著缓解了脚胀,关节组织病理学和病理学得分.
- SPP降低了包括IL-1β和IL-6在内的炎症媒介的血清水平.
- SPP干预重塑了肠道微生物群,增加了像Parabacteroides和Bacteroides这样的有益细菌.
- SPP显著增强了SCFA (酸,酸,黄油酸) 的生产.
结论:
- SPP在类风湿性关节炎 (RA) 中显示出显著的治疗潜力.
- SPP通过调节肠道微生物群组成和增加SCFA产量来发挥其作用.
- 这些SCFA有助于维持肠道屏障功能和免疫平衡,从而减少炎症和缓解RA症状.
更多相关视频
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
08:24Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
相关概念视频
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
