CLDN5:从结构和调节到中枢神经系统疾病以外的瘤和其他疾病中的作用
Yao Ling1, Xinxin Kang1, Ying Yi1
1Department of Histology and Embryology, College of Basic Medical Sciences, Jilin University, Changchun, China; Bethune Second Clinical Medical College of Jilin University, Changchun, China.
Pharmacological research
|January 16, 2024
概括
克劳丁-5 (CLDN5) 对血脑屏障的完整性和中枢神经系统的保护至关重要. 这篇评论探讨了CLDN5的情况.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 病理学 病理学 病理学
背景情况:
- 克劳丁-5 (CLDN5) 是紧结 (TJs) 中的关键蛋白质,对于血脑屏障 (BBB) 完整性和中枢神经系统 (CNS) 恒温是必不可少的.
- 虽然CLDN5在中枢神经系统疾病中的作用已经确立,但其在其他病理中的参与也越来越被认可.
研究的目的:
- 审查克劳丁-5 (CLDN5) 的结构,表达和调节.
- 专注于CLDN5在瘤生长,转移和临床意义上的多方面的作用.
- 提供CLDN5在呼吸道,肠道,心脏和糖尿病眼部疾病中的参与概述.
主要方法:
- 文献综述综合了关于Claudin-5 (CLDN5) 的现有研究.
- 在各种疾病中分析CLDN5表达模式和调节机制.
- 检查CLDN5对细胞表型和疾病进展的影响.
主要成果:
- CLDN5不仅涉及BBB完整性,而且在瘤进展和转移方面也有显著的影响.
- 异常的CLDN5表达与各种疾病的发展相关,包括呼吸道,肠道,心脏和糖尿病眼部疾病.
结论:
- 克劳丁-5 (CLDN5) 是一种关键的调节剂,在中枢神经系统之外具有多种作用,影响瘤发生和多种器官系统疾病.
- 了解CLDN5的复杂功能和调节对于开发用于广泛的人类病理的新型治疗策略至关重要.
关键词:
亚克罗莱因 (PubChem CID: 7847) 是一种蛋白质.氨酸 (PubChem CID: 5950) 的使用情况在 CLDN5 中使用.锡 (PubChem CID: 750) 是一种德克萨米他 (PubChem CID: 5743) 的使用情况甘氨酸 (PubChem CID: 750) 是一种哈洛佩里多尔 (PubChem CID: 3559) 的使用情况脂聚糖化物 (PubChem CID: 53481794) 的使用情况黑色素 (PubChem CID: 896) 的使用情况.非中枢神经系统疾病 非中枢神经系统疾病氨酸 (PubChem CID: 145742) 的使用情况西姆瓦斯塔丁 (PubChem CID: 54454) 是一种药物.紧密的结口是紧密的结口.瘤是一个瘤.相关概念视频
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