诺尼尔在老鼠中诱导抑郁行为,并影响肠道微生物群:剂量依赖的效果
Jiani Pan1, Dezhi Lu1, Leilei Yu2
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Environmental pollution (Barking, Essex : 1987)
|January 16, 2024
概括
在老鼠中,暴露于内分泌干扰物nonylphenol (NP) 可以导致类似抑郁症的行为. NP破坏了肠道屏障,改变了肠道微生物群,并通过肠-脑轴以剂量依赖的方式影响大脑.
科学领域:
- 环境毒理学环境毒理学
- 神经科学是一个神经科学.
- 微生物组研究的研究.
背景情况:
- 诺尼尔 (NP) 是一种在食品中发现的内分泌干扰物.
- 它对行为的影响和潜在的生物机制尚未完全理解.
研究的目的:
- 在大鼠中研究NP暴露和类似抑郁症的行为之间的剂量反应关系.
- 探索NP诱导抑郁的机制,包括神经递质,肠道屏障功能,炎症和肠道微生物群.
主要方法:
- 鼠被暴露在不同剂量的NP中.
- 评估了类似抑郁症的行为.
- 分析了肠道屏障完整性 (zonula occludens protein-1,claudin-1),炎症标记物 (TNF-α,IL-1β),肠道微生物群组成,以及海马中的神经递质.
主要成果:
- 中高剂量的NP降低了肠道屏障蛋白和炎症标志物,导致肠道粘膜受损.
- 暴露于NP改变了肠道微生物群的多样性和短链脂肪酸的合成.
- NP加剧了中枢神经系统损伤和海马中神经递质干扰,与剂量相关.
结论:
- 暴露于nonylphenol会通过对肠-大脑轴的剂量依赖性干扰加剧大鼠的类似抑郁的行为.
- 机制包括肠道屏障受损,肠道微生物群改变,酸盐代谢受损和神经递质失衡.
更多相关视频
07:49Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
Published on: June 2, 2022
3.2K
08:15Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
62
相关概念视频
01:22Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...