MASLD:一种全身代谢障碍,伴有心血管和恶性并发症
Giovanni Targher1, Christopher D Byrne2, Herbert Tilg3
1Metabolic Diseases Research Unit, IRCCS Sacro Cuore Don Calabria Hospital and Department of Medicine University of Verona, Negrar di Valpolicella (VR), Italy giovanni.targher@univr.it.
Gut
|January 16, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为非酒精性脂肪性肝病 (NAFLD),与心血管疾病 (CVD) 和癌症的风险增加有关. 本综述涵盖了MASLD的流行病学,机制和心血管疾病风险管理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一种普遍存在的全球疾病,影响到38%的成年人.
- NAFLD是一种多系统性疾病,与胰岛素抵抗,代谢功能障碍以及严重的肝脏和肝外并发症有关.
- "NAFLD"一词正在被代谢功能障碍相关的脂肪性肝病 (MASLD) 取代,定义之间的一致性很高.
研究的目的:
- 审查有关MASLD及其与心血管疾病 (CVD) 和恶性并发症相关的流行病学数据.
- 探索将MASLD与肝外并发症风险增加联系在一起的机制.
- 讨论MASLD或代谢功能障碍相关的脂肪肝炎 (MASH) 患者心血管疾病风险的诊断和管理.
主要方法:
- 现有文献的叙述性审查.
- 对MASLD流行率和相关风险的流行病学数据的分析.
- 关于心脏病风险评估和治疗的机制研究和临床指南的综合.
主要成果:
- MASLD影响了全球成年人口的很大一部分.
- MASLD与心血管疾病,2型糖尿病,慢性病和某些癌症的风险增加密切相关.
- 新出现的证据显示NAFLD和MASLD定义之间存在很高的一致性.
结论:
- MASLD是一种严重的代谢疾病,具有广泛的系统影响.
- 了解MASLD与肝外并发症之间的联系对于患者管理至关重要.
- 对MASLD/MASH患者心血管疾病风险的有效诊断和治疗策略至关重要.
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