多克萨普拉姆用于早产性呼吸暂停和5-6岁时神经发育结果
Ludovic Tréluyer1,2, Elodie Zana-Taieb2,3, Pierre-Henri Jarreau4,2
1Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, Université Paris Cité, Paris, France ludovic.treluyer@inserm.fr.
Archives of disease in childhood. Fetal and neonatal edition
|January 16, 2024
概括
对早产婴儿的多克萨普拉姆治疗没有显示出长期的神经发育问题. 这项研究没有发现多克萨普拉姆与早产性呼吸暂停和非常早产的儿童的神经发育障碍之间的关联.
科学领域:
- 新生儿医学 新生儿医学
- 发育儿科 发育儿科
- 药理学 药理学是指药理学的学科.
背景情况:
- 过早性呼吸暂停 (AOP) 在怀孕32周之前出生的婴儿中很常见.
- 多克萨普拉姆是一种呼吸系统兴奋剂,有时用于治疗AOP.
- 在这个人群中,多克萨普拉姆对神经发育的长期影响需要进一步研究.
研究的目的:
- 评估多克萨普拉姆在早产婴儿的长期神经发育影响.
- 为了评估AOP治疗的儿童在5-6岁时的结果.
主要方法:
- 法国国家队列的EPIPAGE-2二次分析.
- 基于人口的队列研究,包括在怀孕32周之前出生的婴儿.
- 在5-6岁时进行神经发育评估 (脑,DCD,智商,行为).
- 倾向性得分匹配 (2:1) 控制治疗分配偏差.
主要成果:
- 最初的分析显示,多克萨普拉姆与神经发育障碍之间存在潜在的关联 (OR1.43,p=0.02).
- 在倾向分数匹配后,围产期特征在各组之间相似.
- 匹配分析发现多克萨普拉姆与神经发育障碍之间没有显著的关联 (OR1.09,p=0.63).
结论:
- 对早产性呼吸暂停的多克萨普拉姆治疗与非常早产婴儿的神经发育障碍无关.
- 研究结果表明,多克萨普拉姆不会对这一群体的长期神经发育结果产生负面影响.
- 进一步的研究可能会探索最佳的AOP管理策略.
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