膀保护的三模式疗法用卡佩奇他.
Connor Lynch1, Randy F Sweis2, Parth Modi3
1Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL.
Clinical genitourinary cancer
|January 16, 2024
概括
通过尿道切除膀瘤 (TURBT) 和同时服用capecitabine的三种疗法显示出高的膀控制率. 这种保护膀的方法为肌肉侵入性膀癌患者提供了有效的癌症治疗,低毒性.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学瘤学 医学瘤学
背景情况:
- 肌肉侵入性膀癌 (MIBC) 给那些不适合进行激进囊切除术或标准化疗放射治疗的患者带来了治疗挑战.
- 在MIBC的膀保护策略中,需要使用较低强度的化疗方案.
研究的目的:
- 在MIBC患者中,使用单剂同时使用capecitabine的三模式治疗 (膀瘤最大透尿切除[TURBT]+放射治疗) 的疗效和毒性进行评估.
- 评估这种膀节约治疗方法的膀控制,生存结果和毒性概况.
主要方法:
- 无法接受激进囊管切除或标准化疗或放射治疗的患者接受了最大的TURBT,随后同时接受了capecitabine和放射治疗.
- 用Kaplan-Meier方法对毒性进行了前性监测,并使用Kaplan-Meier方法估计了生存结果 (无进展,癌症特异性,无远程转移,无膀复发).
主要成果:
- 在2013-2023年期间治疗的27名患者中,在膀和骨盆中观察到93%的完全反应率.
- 两年生存率估计包括81%的无进展,65%的癌症特异性,91%的无远程转移和92%的无膀复发生存率.
- 治疗显示出低毒性,有7次3级急性血液/代谢事件,没有其他3级+毒性.
结论:
- 最大TURBT与同时使用capecitabine和放射治疗相结合,是MIBC的有效膀保护选择.
- 这种三种模式治疗实现了高膀控制率,并表现出良好的毒性概况,使其适合特定患者群体.
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