热性细胞死亡:放射治疗的新兴治疗机会
Hongbin Li1, Tiantian Yang1, Jialin Zhang1
1School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050, China.
Cell death discovery
|January 16, 2024
概括
放射治疗 (RT) 可以通过诱导 pyroptotic 细胞死亡来增强,这是一个编程细胞死亡 (PCD) 途径. 这种炎症过程增强了抗瘤免疫力,并改善了癌症治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 放射治疗 (RT) 是癌症治疗的基石,但面临着瘤耐药性和副作用的挑战.
- Pyroptosis是一种炎症编程细胞死亡 (PCD) 途径,涉及细胞胀,膜破裂和细胞因子释放.
- 新出现的证据表明,热可以增强抗瘤免疫反应.
研究的目的:
- 审查辐射诱导热的调节机制.
- 阐明热在增强RT疗效方面的潜在意义.
- 探索热症作为瘤学的新治疗策略.
主要方法:
- 文献综述综合了最近关于辐射诱导热的研究.
- 分析将热与免疫细胞激活和招募联系在一起的机制.
- 讨论烧中介的危险信号释放及其系统性影响.
主要成果:
- 通过RT诱导瘤细胞中的pyroptotic细胞死亡可以刺激抗瘤免疫反应.
- 热酶通过促进免疫细胞透和激活来增强RT的有效性.
- 发放的危险信号从 pyroptotic 细胞可以引起全身抗瘤免疫力,潜在的向转移.
结论:
- 热性细胞死亡代表了改善癌症RT结果的有希望的治疗途径.
- 利用辐射诱导的热亡可能会克服瘤的抵抗力,并提高治疗的疗效.
- 进一步的研究至关重要,以优化用于RT的临床应用的热致死诱导.
更多相关视频
05:08Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
Published on: February 17, 2019
6.2K
11:04An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
Published on: January 13, 2023
3.1K
相关概念视频
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
01:27Tumor Immunotherapy
527
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
527
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K