人母奶油改变了早产婴儿的肠道微生物组:一项前性队列研究
Grace O Adeniyi-Ipadeola1,2, Kristi L Hoffman3, Heeju Yang4
1Graduate Program in Immunology & Microbiology, Baylor College of Medicine, Houston, TX, USA.
Pediatric research
|January 16, 2024
概括
人类奶油补充剂改变了出生体重非常低的婴儿的肠道微生物群,增加了蛋白质细菌和特定的代谢途径. 这种饮食变化会影响早产婴儿的肠道微生物群组成.
科学领域:
- 微生物组研究的研究.
- 婴儿营养 婴儿营养
- 胃肠病学 胃肠病学
背景情况:
- 人母奶油用于增强出生时体重非常低 (VLBW) 婴儿的生长.
- 奶油补充剂对VLBW婴儿肠道微生物群的影响尚不清楚.
研究的目的:
- 为了研究母乳奶油补充剂对VLBW婴儿肠道微生物组合的影响.
主要方法:
- 来自23名VLBW婴儿的便样本的全基因组猎枪测序 (12个对照组,11个奶油组).
- 婴儿接受纯母乳饮食;奶油组从奶油中获得额外的卡路里.
主要成果:
- 没有观察到阿尔法多样性的显著差异.
- 贝塔多样性在各组之间有显著差异.
- 奶油组显示了更高的蛋白质细菌和更低的Firmicutes流行.
- 在奶油组中,Klebsiella物种和脂质代谢途径更为普遍.
结论:
- 奶油补充剂显著改变了VLBW婴儿的肠道微生物组.
- 变化有利于增加蛋白质菌和相关的功能基因含量.
- 早产婴儿的饮食干预可以影响肠道微生物群,并可能影响健康.
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