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早产婴儿的治疗性低温 34-35 周妊娠年龄与新生儿脑病变

Seh Hyun Kim¹, Hoda El-Shibiny¹, Terrie Inder^1,2

¹Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Journal of perinatology : official journal of the California Perinatal Association

|January 16, 2024

概括

治疗性低温 (TH) 是安全有效的早产婴儿出生在34-35周怀孕经历新生儿脑病. 短期结果与36周或更长时间出生的婴儿的结果相似.

科学领域:

新生儿科学新生儿科学
围产儿医学围产儿医学
神经保护是一种神经保护.

背景情况:

新生儿脑病变 (NE) 是新生儿的一种严重疾病.
治疗性低温 (TH) 是预产婴儿中NE的标准治疗方法.
在怀孕34-35周的早产婴儿中,TH的安全性和有效性不太清楚.

研究的目的:

评估新生儿脑病变治疗性低温 (TH) 的短期结果和安全性.
评估在怀孕34-35周的早产婴儿中TH的可行性.

主要方法:

一个匹配的回顾性队列研究.
对比了20名早产婴儿 (34-35周怀孕) 与40名婴儿 (≥36周怀孕) 接受TH (2015-2021).
结果根据出生体重进行了调整.

主要成果:

在接受TH的早产婴儿 (34-35周) 和婴儿 (≥36周) 之间,短期结局是可比的.
在发作,腹腔内出血,输血,皮下脂肪,MRI确认的大脑损伤或死亡率方面没有发现显著差异.
在调整出生体重后,研究结果保持一致.

结论:

治疗性低温 (TH) 是可行的和安全的早产婴儿在34-35周怀孕与新生儿脑病.
对于这个特定的早产人口来说,TH可以被认为是一个可行的治疗选择.
这项研究支持在边界早产婴儿中使用TH.

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