相关实验视频

Updated: Jul 5, 2025

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Published on: March 31, 2015

FGF19及其类似物阿尔达费明与MYC合作,诱导具有侵略性的肝癌发生

José Ursic-Bedoya^1,2, Guillaume Desandré¹, Carine Chavey¹

¹Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France.

EMBO molecular medicine

|January 16, 2024

概括

纤维细胞生长因子19 (FGF19) 显示了代谢益处,但可以驱动肝癌 (HCC). 一种FGF19模拟物Aldafermin也与MYC表现出致癌协同作用,引发了肝脏患者的安全问题.

科学领域:

肝细胞癌 (HCC) 病原发生
在瘤学瘤学.
代谢疾病代谢疾病

背景情况:

纤维细胞生长因子19 (FGF19) 具有不同的代谢功能,包括调节胰岛素敏感性,葡萄糖/脂质代谢和能量平衡.
FGF19被认为是一种致癌驱动因素,特别是在肝细胞癌 (HCC) 中.
目前正在研发FGF19的类似物,以将代谢效益与促进瘤活动分开.

研究的目的:

在临床前小鼠模型中研究FGF19与常见的HCC变异结合的致癌潜力.
评估FGF19模拟Aldafermin (NGM282) 是否保留致癌性质,特别是其与MYC的协同作用.
评估阿尔达费明对肝功能受损的患者的安全影响.

主要方法:

使用了体质突变驱动的HCC的临床前小鼠模型.
评估了FGF19和Aldafermin与p53无活化,CTNNB1突变,CCND1或MYC过度表达相结合的致癌性.
用复合蛋白进行全身治疗,以观察表型变化.

主要成果:

FGF19在HCC发展方面与MYC展现了强大的致癌合作.
这种致癌协同作用与FGF19模拟阿尔达费尔明 (NGM282) 保持一致.
用阿尔达费明短期治疗导致MYC表达性肝细胞的快速增殖.

结论:

与FGF19类似的阿尔达费明具有致癌性,特别是在与MYC的协同作用下.
阿尔达费明并非完全没有原生FGF19.9的促进瘤活动.
由于其保留的致癌性,人们对阿尔达费明在患有肝脏疾病的患者的使用存在担忧.

关键词:

阿尔达费明 (NGM282) 是一种阿尔达费明.联邦政府财政基金19-15 水力动力注射器的使用方法肝癌肝癌是一种癌症.致癌性合作致癌性合作

更多相关视频

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

Published on: April 18, 2025

Cell Type-specific Gene Expression Profiling in the Mouse Liver

Cell Type-specific Gene Expression Profiling in the Mouse Liver

Published on: September 17, 2019

相关概念视频

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...