强迫症的发病年龄不同影响白质微观结构
Chris Vriend1,2, Niels T de Joode3,4, Petra J W Pouwels5,6
1Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, and Department of Anatomy and Neuroscience, de Boelelaan 1117, Amsterdam, the Netherlands. c.vriend@amsterdamumc.nl.
Molecular psychiatry
|January 16, 2024
概括
强迫症 (OCD) 显示白质完整性发生变化,特别是在晚发病的病例中,影响了乳腺体和脑网络的效率. 这些发现凸显了lamus在强迫症病理生理学中的作用.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 之前对强迫症障碍 (OCD) 白质微观结构的扩散MRI研究产生了不一致的结果.
- 挑战包括人口结构的变化,临床因素,扫描方法和小样本大小.
研究的目的:
- 通过协调来自一个大型,多个地点的国际研究的数据来识别强迫症的可复制和可概括的大脑特征.
- 与对照人群相比,研究强迫症成年人的白质微观结构和结构连接体差异.
- 为了检查强迫症发病的早期与晚年对大脑结构的影响.
主要方法:
- 利用单和多扩散MRI测量,包括神经元导向分散和密度成像 (NODDI),以及基于fixel的分析.
- 从260名强迫症成年人和252名健康对照人群的骨化白质段中提取了测量结果.
- 进行结构连接组分析,采用混合模型和贝叶斯多层次分析.
主要成果:
- 与对照人群相比,强迫症的成年人表现出较高的纤维密度在松层.
- 与早期发病病例相比,晚期发病的强迫症病例显示后部乳头辐射的完整性降低 (辐射扩散率增加) 和全球结构连接体效率降低.
- 后期分析显示,与对照组相比,早期和晚期出现的强迫症组中白质变化的明显模式.
结论:
- 强迫症发病的年龄显著影响着柱-柱/柱管中的白质完整性以及大脑结构网络的整体效率.
- 研究结果支持在强迫症的病理生理学中涉及甲状腺,其 afferent 途径和视觉注意力过程.
- 这项研究为与强迫症相关的特定白质变化提供了强有力的,协调的证据,区分了发病类型.
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