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Updated: Jul 5, 2025

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
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在酵母和胰腺管道腺癌细胞中,SUMOylation调节eIF5A活动

Rocío Seoane1,2, Tomás Lama-Díaz1,3, Antonia María Romero4,5

  • 1Centro de Investigación en Medicina Molecular (CIMUS), IDIS, Universidade de Santiago de Compostela, Avda Barcelona, 15706, Santiago de Compostela, Spain.

Cellular & molecular biology letters
|January 16, 2024
PubMed
概括

细胞转化启动因子5A (eIF5A) 被SUMO2SUMOylated,这是压力诱导的修饰,影响其稳定性,局部化和在酵母和人类细胞中的功能. 这种修饰对于细胞适应热冲击至关重要,并促进胰腺癌细胞的生长和迁移.

关键词:
胰腺管道腺癌瘤这就是SUMO2的价值.压力颗粒是压力颗粒.压力反应应对压力的反应在 eIF5A 中,eIF5A 是

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