与认知衰退和痴呆症相关的自我和采访者报告的认知问题:来自两个前性研究的结果
Yuhui Huang1, Hui Chen1, Mengyan Gao1
1School of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
BMC medicine
|January 16, 2024
概括
采访者报告的认知问题 (ICP) 可能标志着老年人的早期认知衰退和痴呆风险. 将ICP与自我报告的认知问题 (SCP) 结合起来,显示出与认知衰退和痴呆症的最强相关性.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 对采访者报告的认知问题 (ICP) 与与年龄相关的认知衰退相关的有限理解.
- 调查ICP和自我报告的认知问题 (SCP) 与认知衰退和痴呆症的独立和联合关联.
研究的目的:
- 评估面试者报告的认知问题对认知衰退和痴呆症的预测价值.
- 检查自我报告和采访者报告的认知问题的综合影响对认知轨迹.
主要方法:
- 分析了两个潜在的队列:中国健康和退休长度研究 (CHARLS) 和欧洲健康,衰老和退休调查 (SHARE).
- 包括10976名中国和40499名没有痴呆症的欧洲成年人.
- 使用验证的尺度定义SCP和ICP;通过客观测试和事件痴呆症评估认知衰退;使用随机效应模型进行聚合分析.
主要成果:
- ICP独立地与更快的认知衰退相关 (例如,在CHARLS中β = -0.025/年).
- 无论是ICP还是SCP,都独立地增加了痴呆症风险 (SCP的RR总值=1.73,ICP=1.40).
- 同时存在的SCP和ICP证明了与加速认知衰退 (汇总β=-0.035/年) 和最高痴呆风险 (汇总RR=2.29) 的最强的关联.
结论:
- 面试官报告的认知问题是潜在的认知衰退和痴呆症的早期指标.
- 自我和采访者报告的认知问题的组合显示出与不良认知结果的最显著联系.
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