在败血症中影响DVT形成的因素
Lu Wang1, Xudong Ma2, Yujie Chen1
1Department of Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Thrombosis journal
|January 16, 2024
概括
患有败血症,高血压和心房的老年患者更容易发生深静脉血栓症 (DVT). 较差的肝功能和更好的凝血/呼吸增加了败血症患者的DVT风险,导致更长的ICU停留.
科学领域:
- 心血管疾病 心血管疾病
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
背景情况:
- 败血症是一个重大的全球健康挑战.
- 深静脉血栓 (DVT) 是心血管死亡的主要原因.
- 了解败血症中DVT风险因素对于患者的治疗结果至关重要.
研究的目的:
- 为了调查与DVT发育相关的因素在败血症患者.
- 在这个人群中确定DVT的临床和实验室预测因素.
- 分析DVT对败血症患者预后的影响.
主要方法:
- 在北京联合医学院医院接受DVT查的918名败血症患者的调查.
- 数据收集时间从2013年6月到2022年10月.
- 分析包括人口统计,并发症,炎症标志物,白蛋白,SOFA分数,凝血和器官功能.
主要成果:
- 败血症患者的DVT患病率为23%.
- 老年患者和患有高血压或心房的患者表现出较高的DVT率.
- 血清白蛋白水平与DVT相关;较差的肝功能和更好的凝血/呼吸与DVT有关.
- 患有DVT的患者经历了更长的机械呼吸和ICU停留,但生存率相似.
结论:
- 败血症相关的DVT受年龄,并发症和器官功能的影响.
- 虽然炎症标志物和SOFA评分不是重要的预测因素,但凝血,呼吸和肝功能起着关键作用.
- 败血症中的DVT与长时间的重症监护和住院有关,这强调了针对性预防策略的必要性.
相关概念视频
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Disorders of Hemostasis
918
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
918
Anticoagulant Drugs: Low-Molecular-Weight Heparins
701
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
701
Clot Retraction and Fibrinolysis
6.0K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.0K
Extrinsic and Intrinsic Pathways of Hemostasis
7.7K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
7.7K
Venous Return
4.3K
The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
4.3K


