咳与非典型帕金森症中的功能性吞结果相关
Michela J Mir1,2, Justin T Childers3, Karen Wheeler-Hegland4,5
1Breathing Research and Therapeutics Center, Department of Physical Therapy, University of Florida, Gainesville, Florida, USA.
在非典型的帕金森症 (APD) 中吞困难与咳功能受损有关,特别是在疾病持续时间较长的情况下. 早期评估吞和咳对于APD患者有效的气道保护策略至关重要.
科学领域:
- 神经学 神经学
- 语音语言病理学 语言病理学
- 肺部病理学 肺部病理学
背景情况:
- 吞和咳障碍会导致吸血和减少分泌物清除.
- 众所周知,这些行为在帕金森病中受损.
- 在非典型帕金森症 (APD) 中吞和咳功能障碍之间的关系尚不清楚,需要进一步调查,以便及时保护呼吸道.
研究的目的:
- 调查APD患者的吞缺陷和咳功能受损之间的关联.
- 为了确定APD中呼吸道保护功能障碍是否与疾病持续时间相关.
主要方法:
- 在11名患有APD的参与者中评估了吞困难.
- 从视频光镜吞研究报告中提取了薄液体试验的透吸收量 (PAS) 和DIGEST分数.
- 分析了自愿和素诱导的反射咳措施,包括流量,体积和时间.
主要成果:
- 大约80%的APD参与者表现出异常的PAS分数,并报告吞困难.
- 异常的PAS分数与减少自愿咳 expired体积和反射吸气流量,以及更长的反射吸气流量上升时间有关.
- 较高的PAS分数与反射咳体积加速减少相关,较长的疾病持续时间预测了更大的自愿咳过期体积和更长的流量上升时间.
结论:
- 在APD中吞安全性的恶化可能与咳对气道清除效率的降低相吻合,特别是在疾病进展时.
- 评估吞功能和咳对于开发APD中全面的气道保护策略至关重要.
- 这些发现强调了综合评估对于管理APD的气道风险的重要性.
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