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氧化马丁通过氧化还原系统调节阻碍了内毒素诱导的玻璃眼的进展

Ashmita Das¹, Onkar Kashyap¹, Devi P Pandey²

¹Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India.

Journal of biochemical and molecular toxicology

|January 17, 2024

概括

氧马丁 (OMT) 通过减少炎症和氧化应激,有效地预防大鼠内毒素诱导的玻璃眼. 这种化合物使眼内压力正常化,并保护视网膜血管,提供了有前途的玻璃眼癌治疗方法.

科学领域:

眼科医生眼科眼科
药理学药理学是指药理学的学科.
毒理学毒理学毒理学

背景情况:

玻璃眼是导致不可逆转失明的主要原因.
在研究疾病机制和测试治疗方法方面,内毒素诱导的紫外线性玻璃眼模型至关重要.
氧马丁 (OMT) 具有抗炎,抗氧化和TNF-α对抗性质.

研究的目的:

在Wistar大鼠的内毒素诱导的玻璃眼模型中提供证据证明oxymatine (OMT) 的预防作用.
研究OMT的作用机制,重点关注其抗炎,抗氧化和TNF-α对抗性质.

主要方法:

在Wistar大鼠中,使用局部脂聚糖化物 (LPS) 诱导了Uveitic光眼.
治疗组接受不同剂量的OMT (0.25%,0.5%,1%) 或多佐胺 (1%) 局部为15天.
评估包括实时视网膜血管成像,透镜图像和抗氧化系统,TNF-α活性,ATPase和离子活动的生物化学分析.

主要成果:

诱导LPS导致眼内压 (IOP) 升高,抗氧化系统中断,脂质损伤,TNF-α升高,ATPase/离子活动改变.
视网膜血管损伤和晶状体模糊在青光眼对照组中观察到.
1%的OMT剂量显著提高了抗氧化剂水平,使细胞内离子和ATPase正常化,降低了TNF-α活性,并抵消了眼睛的变化,使IOP正常化.

结论:

氧马丁 (OMT) 显示出对大鼠内毒素诱导的玻璃眼的显著预防作用.
OMT的治疗效益归因于其强大的抗氧化,抗炎和TNF-α抑制作用.
OMT显示出作为一种新且有效的玻璃眼治疗方法的承诺,能够使眼内压力正常化.

关键词:

在LPS中使用LPS.这就是TNF-α.生物化学分析的方法玻璃眼 glaucoma 玻璃眼玻璃眼玻璃眼玻璃眼氧化氨酸是一种氧化胺.

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