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在现场使用合成纳米材料对免疫细胞进行重新编程

Shihong Nie¹, Yuyang Qin^1,2, Liyuan Ou²

¹Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.

Advanced materials (Deerfield Beach, Fla.)

|January 17, 2024

概括

在现场细胞疗法为复杂而昂贵的CAR-T细胞制造提供了一个有希望的替代方案,用于癌症治疗. 这种方法使用合成纳米材料来重编程体内的免疫细胞,提高可访问性.

科学领域:

生物医学工程生物医学工程
免疫学免疫学免疫学
纳米技术纳米技术

背景情况:

化学抗原受体-T (CAR-T) 细胞疗法改变了癌症治疗,但面临着制造方面的挑战.
高昂的成本和复杂性限制了当前采用细胞疗法的可访问性.
现场细胞疗法成为一种可行的替代方案,它可以直接在体内重新编程免疫细胞.

研究的目的:

提供合成纳米材料在现场免疫细胞重编程的概述.
专注于这些纳米材料在现场CAR疗法中的应用.
讨论挑战,并提出解决方案,用于临床翻译的 in situ 免疫细胞重编程.

主要方法:

核酸输送 (等离子体DNA和mRNA) 的合成纳米材料开发近期进展的审查.
专注于纳米材料介导的交付,用于T细胞和巨细胞的现场重编程.
对现场CAR疗法开发策略的分析.

主要成果:

合成纳米材料显示了为在位免疫细胞重编程提供遗传材料的潜力.
在现场CAR疗法是一个关键的重点,利用这些纳米材料.
确定了实现有效和安全的现场重新编程的关键挑战.

结论:

通过合成纳米材料实现的局部细胞疗法,为癌症免疫疗法提供了一种可扩展和可访问的方法.
克服当前的挑战对于在位免疫细胞重编程的临床应用至关重要.
需要对纳米材料设计和交付进行进一步的研究,才能充分发挥这种治疗策略的潜力.

关键词:

在LNP,mRNA.在PBAEE中,PBAE是PBAE 仿制性抗原受体的复制体.在现场进行重新编程.

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