基础代谢率与心血管疾病之间的关联:一个双样本的门德尔随机化研究
Kaijie Chen1, Yue Zhang1, Siyu Zhou1
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
European journal of clinical investigation
|January 17, 2024
概括
较高的基础代谢率 (BMR) 可能因果性地增加心肌病,心力衰竭和膜心脏病的风险. 这项研究使用了门德尔的随机化来研究BMR与心血管疾病的联系.
科学领域:
- 遗传学和心血管医学
- 代谢研究研究 代谢研究
背景情况:
- 研究基底代谢率 (BMR) 和心血管疾病之间的因果关系对于了解疾病病因至关重要.
- 门德尔随机化 (MR) 提供了一种强大的方法,可以使用遗传变异推断因果关系.
研究的目的:
- 阐明基因预测的基底代谢率 (BMR) 对患常见心血管疾病的风险的潜在因果影响.
- 区分直接的因果关系与BMR与各种心血管疾病之间的纯粹关联.
主要方法:
- 利用了英国生物银行的大规模全基因组关联研究 (GWAS) 数据集 (n=331,307) 的欧洲血统.
- 采用孟德尔的随机化与单核酸多态 (SNPs) 强烈与BMR作为仪器变量相关.
- 应用逆方差加权 (IVW) 分析和灵敏度分析 (MR-Egger,加权中位数,MR-PRESSO) 来评估变性和异质性.
主要成果:
- 基因预测的BMR增加与心肌病 (OR=2.00),心力衰竭 (OR=1.39) 和膜心脏病 (OR=1.18) 的风险增加有显著关联.
- 在BMR和冠状动脉疾病 (OR=0.96) 之间没有明确的因果关系.
- 在BMR和心房动 (AF) (OR=1.85) 之间观察到强烈的关联,尽管结论指出,在初级发现的背景下,这不是一个明确的因果关系.
结论:
- 较高的基础代谢率 (BMR) 似乎对心肌病,心力衰竭和膜性心脏病的风险产生因果关系.
- 这项研究表明,BMR可能不是冠状动脉疾病的直接因果因素.
- 需要进一步研究BMR和心房动之间的复杂关系.
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