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Updated: Jul 5, 2025

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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化依索因多林基葡萄糖胺基合成酶抑制剂与低人体剂量预测

H Marie Loughran1, Kathy M Schirripa1, Anthony J Roecker1

  • 1Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

ACS medicinal chemistry letters
|January 17, 2024
PubMed
概括

研究人员优化了葡萄糖胺合成酶 (GCS) 抑制剂用于帕金森病 (PD). 替代改善了口服生物可用性,中枢神经系统的透,并减少了药物流出,从而产生了有前途的新化合物.

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